Custom Synthesis

Whether you require milligram or kilogram quantities of material, TimTec provides custom organic synthesis using the latest technology. Our facilities are available for production of intermediates as well as Active Drug Substances under cGMP requirements.

Whether your need is for milligram or kilogram quantities of material, TimTec provides custom organic synthesis using the latest technology. Our facilities are available for production of intermediates as well as Active Drug Substances under cGMP requirements. Allow us to review your chemical needs and quickly respond with a detailed project plan and quotation. You can be assured that your project will receive high priority and personal attention. Our expertise is in rapid scale-up without sacrificing product quality, and we strictly adhere to all environmental and safety regulations. All inquiries are held in the utmost confidence.

Quality Control and Compound Purity

TimTec determines structure and purity of all compounds by using NMR and mass spectrometry. Our compounds have an average purity of 95%, and the minimum purity is at least 90%. We randomly check the quality of our stock compounds on a regular basis to confirm stability and shelf life. 1H-NMR spectra are available upon request for all stock compounds.

Analytical Services

• HPLC Method Development and Validation
• Finished Product Testing
• Raw Material Testing
• Stability Testing

Analysis is performed in an FDA and DEA registered laboratory.

NMR Services

• The service can be provided for compounds from your sample bank or those from vendors need structural confirmation.
• Capacity: 5,000-10,000 NMR spectra per month.
• Instruments: six ranging from 300 to 500 MHz set up as a network.
• Spectra: with structural assignment can be provided in electronic format as printable files (*.lsr) or/and FID-files.

Sample Handling - Weighting, Plating, Compound Library Management

•    Dry and liquid sample handling
•    From small scale (even few samples) to high throughput handling capability
•    Fully automated high throughput liquid handling systems
•    Organizing and Re-formatting of Chemical Libraries according to custom requirements
•    Transferring samples from old storage vessels to the robot adjustable vials and plates with chemically resistant bar-coded labels.
•    Dissolving precisely weighed out samples in fixed or variable volumes of solvent such as DMSO.
•    Preparation of multiple sets and replication of 96 and 384 well plates, storage plates (in dry or liquid forms), mother and daughter plates.
•    Electronic structural records and digital inventory organization and tracking
•    Barcoding and labeling
•    Dry ice domestic and international shipments

Please contact us for a quote for your next custom sample management job. We have capability to do not only single projects, but also accommodate ongoing dry sample and liquids handling support for very small scale and high throughput volumes dedicating more than one automated system if required.

Weighing

Because of our extensive decades-long experience in compound management, we are capable of processing thousands of compounds each month while maintaining the highest handling quality standards. If you have a collection of compounds that needs to be placed into vials, microtiterplates, or other storage vessels, labeled and bar-coded, our professional service can help you accomplish this task quickly and efficiently. Each weighed sample will be placed into one or more vials or microplate tubes 2-D bar coded or conventional, and each sample's data recorded in your preferred database format.

Most frequently we serve as a formatting intermediary point between you and your suppliers, greatly simplifying the daunting task of weighing, plating, labeling, and organizing the chemical libraries being shipped to you. We take on even the smallest projects freeing you from the need to keep largely unutilized specialty equipment and tools while keeping all your samples in uniform and ready to use format.

Fully Automated High-Throughput Liquid Handling

We are using Tecan Freedom automated systems that offer industry accepted and time-tested precision and speed for handling 100nL-5000uL volumes. The equipment is operated by Tecan certified specialist.

One system can process up to 33 plates in one batch efficiently using 96 and 384 multi-channel arm. It takes less than 1.5min to replicate 96-well plate and less than 5 minutes to complete a 384-well plate. The systems can be calibrated to work with custom plates and other sample storage vessels.

Plating Services

One of our specialty services where we have considerable experience is preparing samples in plates and microplates including footprint or single 2-D barcode reading. This process can help reorganize chemical libraries to improve inventory system or better prepare them for future screening cycles, where evaluation will be accomplished faster and more efficiently. We can organize your samples according to any specifications you may have. We record all data including structure (if available and is not covered by CDA), weighed amounts, solvent volumes, plate and well locations or other storage solutions coordinates for you in database format or spreadsheets, so the process of data transfer and retrieval is accurate, quick and easy.

Custom Bar-Coded Labels

Bar coding can use your internal code system or assign a unique sequential bar code number to each label for corresponding storage container.

Compound Management and Acquisition

Purchasing large numbers of compounds from multiple suppliers can be arduous and time consuming. Even after desirable agents are found, a significant amount of work is necessary for each supplier's shipment to satisfy a customer's database formatting, weight, solution, and vessel requirements.

TimTec serves many of its clients as a purchasing agent and centralized point of organization when chemical compound purchases from many separate sources are necessary. We perform the work of repackaging these multi-source compounds in a uniform manner, applying bar code labeling to plates and vials, managing the data in SD and/or ISIS Base format, and then delivering the compounds in the form required by your screening program. If desired, TimTec can also expeditiously and accurately spot-check compounds for correct quantities and assess quality with our NMR spectrometry services.

Services include 

• Placing orders to multiple suppliers
• Receiving and checking shipment content
• Performing quality control of received samples (NMR services)
• Preparing database files according to customer specifications
• Repackaging samples into standard vials
• Custom weighing into vials or microplates (conventional or 2-D coded tube systems)
• Preparing DMSO solutions in storage, mother and daughter plates
• Applying custom bar-coded labels to vials and plates.

Performing computational services: diversity analysis, lipophilicity calculation (LogP), solubility (LogSw) and absorption (FA) determinations